Which of the following is NOT a type of skin lesion?

Wrinkles are not classified as skin lesions. While they are visible changes to the skin, they represent a natural part of the aging process and the result of repeated movements and sun exposure, rather than a distinct pathological alteration or abnormality in the skin tissue.

On the other hand, pustules, nodules, and macules are all types of skin lesions. Pustules are small, inflamed, pus-filled lesions commonly associated with acne. Nodules are larger, solid bumps that can be found deeper in the skin and may require medical evaluation. Macules are flat, discolored spots on the skin that differ from the surrounding area, often indicating various dermatological conditions. The clear distinction is that lesions are typically associated with some form of abnormality or change in the skin's structure, while wrinkles signify a natural progression rather than a pathological condition.